The effects of partial βαρύτητα (example on Μάρτιος) on our muscular system is still partly understood. Study in rats shows that resveratrol, a compound found in grape skin and red wine, can mitigate muscle impairment in a Μάρτιος μερικώς βαρύτητα model. This can be beneficial to sustain long-term Μάρτιος αποστολές.
Η Εθνική Διοίκηση Αεροναυτικής και Διαστήματος (NASA) of USA is planning to send astronauts to Moon and Μάρτιος. Η μικροβαρύτητα είναι γνωστό ότι επηρεάζει το μυϊκό σύστημα του σώματός μας καθώς μύες and bones start to become weak. First, weight-bearing muscles like soleus, located in the calf are affected and then slow-twitch muscle fibers are lost. του Άρη gravitational pull is only 40 percent of Earth’s thus it has a lower gravity of 0.38g. It is still not completely understood how such μερική βαρύτητα can affect our body. No partial weight-bearing model has been tested until now which can mimic Martian partial gravity. More understanding in this area is critical in order to plan long space missions to Μάρτιος and safe return of astronauts to Earth.
Μια νέα μελέτη που δημοσιεύθηκε στις 18 Ιουλίου στο Όρια Φυσιολογίας has used recently developed partial weight-bearing animal models of simulated Μάρτιος partial gravity to understand how muscle deconditioning could be addressed on long Μάρτιος space missions. To simulate gravity of Μάρτιος, rats were fitted with full-body harness and were suspended from their cage ceiling. Divided into two groups, rats were exposed to normal loading (of Earth’s) or 40 percent loading of Μάρτιος for 2 weeks. Half the number of rats in each group received either ρεσβερατρόλη (RSV) – μια ασφαλής πολυφαινόλη που βρίσκεται συνήθως στη φλούδα των σταφυλιών, στο κόκκινο κρασί και στα βατόμουρα – στο νερό ή μόνο στο νερό. Τα ζώα τρέφονταν ελεύθερα με δίαιτες τσόου.
In Μάρτιος condition, rats’ grip weakened and their calf circumference, muscle weight and slow-twitch fiber content got shrunk. Calf circumference and front and rear paw grip force were measured weekly while calf muscles were analyzed after 2 weeks . Results showed that a moderate daily dose (150 mg/kg/day) of resveratrol was seen to preserve muscle mass and strength in animals exposed to the effects of a simulated Μάρτιος gravity. RSV helped restore front and rear paw grips and protected muscle mass in Μάρτιος rat while having no effect on diet or body weight. RSV is known to have anti-inflammatory, anti-oxidative and anti-diabetic effects. It has been shown to promote muscle growth in diabetic animals by increasing insulin sensitivity and glucose uptake in muscle fibers. Astronauts are thought of developing reduced insulin sensitivity during space missions.
Resveratrol is seen to have a muscle-protective effect as it preserves bone and muscle mass. The current study suggests that resveratrol can help to mitigate muscle impairment in a Μάρτιος partial gravity analog which mimics Μάρτιος environment. It could be used as a nutritional supplement to reduce muscle and skeletal deconditioning and deterioration on long-term Μάρτιος αποστολές.
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{Μπορείτε να διαβάσετε την αρχική ερευνητική εργασία κάνοντας κλικ στον σύνδεσμο DOI που δίνεται παρακάτω στη λίστα των αναφερόμενων πηγών}
Πηγές)
Mortreux, M. 2019. Μια Μέτρια Ημερήσια Δόση Ρεσβερατρόλης Μετριάζει την Αποκατάσταση των Μυών σε ένα Ανάλογο Αρειανής Βαρύτητας. Εμπρός. Physiol.
https://doi.org/10.3389/fphys.2019.00899
